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10.1016/j.ijcard.2014.06.045 Int J Cardiol

Topiramate affects carbonic anhydrase and enhances GABA signaling, while semaglutide activates GLP-1 receptors to reduce appetite and slow gastric emptying

Secondary concerns include altered perception of medication tolerance (cannabis-induced appetite suppression mimicking drug efficacy), reduced motivation for healthy lifestyle changes that enhance GLP-1 outcomes, and potential delayed medical evaluation if serious adverse events occur

However, two practical interactions are worth noting for research protocols

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